Joydeep Bhadury
Postdoctoral Scholar

Joy is a postdoctoral researcher under the mentorship of Professor Hiromitsu Nakauchi. He earned his undergraduate degree in Genetic Engineering in India and completed both his M.S. and Ph.D. in Sweden. During his doctoral studies, he focused on the molecular aspects of cancer biology, targeting genetic and epigenetic mechanisms for translational research under the guidance of Professor Jonas Nilsson.

His research is driven by the belief that understanding cancer at the molecular level can help develop strategies to prevent pluripotent stem cells from acquiring malignant traits—an essential step toward ensuring their safety for clinical applications.

Joy’s long-term goal is to generate transplantation-ready whole human organs in research animals. Toward this goal, his current work focuses on several key areas:

• Defining conditions for capturing a "true state" of mammalian pluripotency: His team has discovered a single condition capable of maintaining pluripotency across species.

• Identifying, defining, and overcoming developmental xeno-barriers: Through both knowledge-based and unbiased genome-wide approaches, he aims to identify and overcome the barriers that limit cross-species organogenesis.

• Developing a damage-free ex vivo organ preservation method: Inspired by natural processes, he is working to develop innovative preservation solutions that could improve transplantation outcomes.

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Selected Publications:

• Bhadury J, López MD, Muralidharan SV, Nilsson LM, Nilsson JA. Identification of tumorigenic and therapeutically actionable mutations in transplantable mouse tumor cells by exome sequencing. Oncogenesis. 2013 Apr 15;2(4):e44. doi: 10.1038/oncsis.2013.8. PMID: 23588493; PMCID: PMC3641362.

• Bhadury J, Nilsson LM, Muralidharan SV, Green LC, Li Z, Gesner EM, Hansen HC, Keller UB, McLure KG, Nilsson JA. BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2721-30. doi: 10.1073/pnas.1406722111. Epub 2014 Jun 16. PMID: 24979794; PMCID: PMC4084424.

• Bhadury J, Einarsdottir BO, Podraza A, Bagge RO, Stierner U, Ny L, Dávila López M, Nilsson JA. Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts. Oncotarget. 2016 Apr 26;7(17):23801-11. doi: 10.18632/oncotarget.8181. PMID: 27009863; PMCID: PMC5029664.

• Alaei-Mahabadi B, Bhadury J, Karlsson JW, Nilsson JA, Larsson E. Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13768-13773. doi: 10.1073/pnas.1606220113. Epub 2016 Nov 16. PMID: 27856756; PMCID: PMC5137778.

• Nishimura T, Suchy FP, Bhadury J, Igarashi KJ, Charlesworth CT, Nakauchi H. Generation of Functional Organs Using a Cell-Competitive Niche in Intra- and Inter-species Rodent Chimeras. Cell Stem Cell. 2021 Jan 7;28(1):141-149.e3. doi: 10.1016/j.stem.2020.11.019. Epub 2020 Dec 28. PMID: 33373620; PMCID: PMC8025673.