Aaron Tan
PhD Student

Aaron Tan was born and raised on the sunny island of Singapore. He graduated from The University of Edinburgh in the United Kingdom with a BSc (First Class Honours) in Development, Regeneration, and Stem Cell Biology. As an undergraduate, he conducted his thesis in Professor Ian Chambers' lab, where he investigated the function of DNA-binding residues in NANOG, a critical pluripotency factor, focusing on its role in supporting cytokine-independent self-renewal of embryonic stem cells. Currently, Aaron is working on the application of highly multiplexed technologies to study hematopoietic stem cells at single-cell resolution, as well as exploring hematopoietic stem cell metabolomics. Outside the lab, he enjoys discovering Asian cuisine across the Bay Area and spends his free time hiking and biking in California’s sunny outdoors.

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Selected Publications:

• Igarashi KJ, Kucinski I, Chan YY, Tan TK, Khoo HM, Kealy D, Bhadury J, Hsu I, Ho PY, Niizuma K, Hickey JW, Nolan GP, Bridge KS, Czechowicz A, Gottgens B, Nakauchi H, Wilkinson AC. Physioxia improves the selectivity of hematopoietic stem cell expansion cultures. Blood Adv. 2023 Jul 25;7(14):3366-3377. doi: 10.1182/bloodadvances.2023009668. PMID: 36809781; PMCID: PMC10345863.

• Charlesworth CT, Homma S, Suchy F, Wang S, Bhadhury J, Amaya AK, Camarena J, Zhang J, Tan TK, Igarishi K, Nakauchi H. Secreted Particle Information Transfer (SPIT) - A Cellular Platform for In Vivo Genetic Engineering. bioRxiv [Preprint]. 2024 Jan 12:2024.01.11.575257. doi: 10.1101/2024.01.11.575257. PMID: 38260654; PMCID: PMC10802600.

• Ho DLL, Lee S, Du J, Weiss JD, Tam T, Sinha S, Klinger D, Devine S, Hamfeldt A, Leng HT, Herrmann JE, He M, Fradkin LG, Tan TK, Standish D, Tomasello P, Traul D, Dianat N, Ladi R, Vicard Q, Katikireddy K, Skylar-Scott MA. Large-Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors. Adv Healthc Mater. 2022 Dec;11(24):e2201138. doi: 10.1002/adhm.202201138. Epub 2022 Nov 22. PMID: 36314397; PMCID: PMC10234214.

• Tan HK, Toh CX, Ma D, Yang B, Liu TM, Lu J, Wong CW, Tan TK, Li H, Syn C, Tan EL, Lim B, Lim YP, Cook SA, Loh YH. Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking. Stem Cells Transl Med. 2014 May;3(5):586-98. doi: 10.5966/sctm.2013-0195. Epub 2014 Mar 19. PMID: 24646489; PMCID: PMC4006490.