Shota Homma
Life Science Research Professional
Administrative Associate for Dr. Nakacuhi
Lab Manager

Shota Homma is a Life Science Research Professional in the Nakauchi Lab at Stanford University School of Medicine, where he contributes to the development of Secreted Particle Information Transfer (SPIT), a novel platform for in vivo genetic engineering, in collaboration with Dr. Carsten Charlesworth. He also leads bench work on the lab’s viral-like particle (VLP) project, addressing low editing efficiency in VLP-Cas9 systems and improving gene-editing delivery to hematopoietic stem cells (HSCs). As lab manager, Shota oversees daily operations, including equipment maintenance, biosafety compliance (APB, APLAC, SCRO, IRB), inventory, training, and inspections, and he works closely with the lab’s financial analyst to track budgets and reconcile expenses. As the bilingual administrative secretary for Dr. Hiromitsu Nakauchi, Shota facilitates the lab’s scientific and academic initiatives. He manages Dr. Nakauchi’s schedule, oversees internal and external communications in both Japanese ad English, and supports coordination of multi-institutional collaborations. He assists with manuscript submissions and travel logistics, and often serves as a bridge between Stanford and international research partners, particularly those in Japan.

Shota holds a Master of Science from Johns Hopkins University and dual undergraduate degrees from UCLA. Outside the lab, he is a classical pianist with over 20 years of training and performance experience. He has performed at venues such as Carnegie Hall and Royce Hall and has has received recognition in several statewide, national and international competitions including first places at the Music Teachers Association of California (MTAC) Piano Solo Competition Division III State Finals; the Music Teachers National Association (MTNA) Piano Solo Competition Division III California State Division; the Pacific Musical Society Piano Competition; second places in the MTNA Southwest Division National Competition as the representative of California, the American Protege International Piano and Strings Competition, and the Rio Hondo Symphony Young Artists Competition. 

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Selected Publications:

• Carsten T. Charlesworth, Shota Homma, Fabian Suchy, Sicong Wang, Joydeep Bhadhury, Anais K. Amaya, Joab Camarena, Jinyu Zhang, Tze Kai Tan, Kyomi Igarishi, Hiromitsu Nakauchi. Secreted Particle Information Transfer (SPIT) – A Cellular Platform for In Vivo Genetic Engineering  bioRxiv 2024.01.11.575257; doi: https://doi.org/10.1101/2024.01.11.575257

• Charlesworth, C. T., Homma, S., Amaya, A. K., Dib, C., Vaidyanathan, S., Tan, T.-K., Miyauchi, M., Nakauchi, Y., Suchy, F. P., Wang, S., Igarashi, K. J., Cromer, M. K., Dudek, A. M., Amorin, A., Czechowicz, A., Wilkinson, A. C., & Nakauchi, H. (2025). Highly efficient in vivo hematopoietic stem cell transduction using an optimized self-complementary adeno-associated virus. Molecular Therapy Methods & Clinical Development. https://doi.org/10.1016/j.omtm.2025.100233

• ​Chu SN, Soupene E, Sharma D, Sinha R, McCreary T, Hernandez B, Shen H, Wienert B, Bowman C, Yin H, Lesch BJ, Jia K, Romero KA, Kostamo Z, Zhang Y, Tran T, Cordero M, Homma S, Hampton JP, Gardner JM, Conklin BR, MacKenzie TC, Sheehan VA, Porteus MH, Cromer MK. Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells. Cell Rep. 2025 Jan 28;44(1):115141. doi: 10.1016/j.celrep.2024.115141. Epub 2025 Jan 3. PMID: 39754719.

• Kano M, Mizutani E, Homma S, Masaki H, Nakauchi H. Xenotransplantation and interspecies organogenesis: current status and issues. Front Endocrinol (Lausanne). 2022 Aug 5;13:963282. doi: 10.3389/fendo.2022.963282. PMID: 35992127; PMCID: PMC9388829.

• Toral MA, Charlesworth CT, Ng B, Chemudupati T, Homma S, Nakauchi H, Bassuk AG, Porteus MH, Mahajan VB. Investigation of Cas9 antibodies in the human eye. Nat Commun. 2022 Feb 25;13(1):1053. doi: 10.1038/s41467-022-28674-1. Erratum in: Nat Commun. 2022 Apr 12;13(1):2109. PMID: 35217666; PMCID: PMC8881612.